# Stanic Lab — Reproductive Immunology
> University of Wisconsin-Madison, Dept. of Obstetrics and Gynecology
> Led by Dr. Aleksandar Stanic-Kostic (MD, PhD)
> Associate Professor with Tenure | Vice Chair for Research | Division Director, Reproductive Sciences

## Pages
- [Home](index.html): Lab overview, mission, research highlights, team preview
- [People](people.html): Team members, collaborator network, alumni
- [Research](research.html): Research directions, publications, methods, model systems
- [News](news.html): Lab news, UW OB/GYN news mirror, photo gallery, timeline

## Research Themes
1. **Maternal-Fetal Tolerance** — Decidual T cell biology, temporal immune dynamics, restraint gene mechanisms
2. **Preeclampsia Immunopathology** — Immune-endothelial crosstalk, checkpoint dysregulation, network topology
3. **PCOS Immune Mechanisms** — Ovarian-specific inflammation, CITE-seq profiling, macaque models
4. **Spatial Transcriptomics** — Cross-gestational atlas of primate maternal-fetal interface (Visium FFPE)
5. **Translational Platforms** — Microphysiological systems, digital pathology, AI/ML integration

## Key Methods
- Visium FFPE Spatial Transcriptomics
- CITE-seq (simultaneous protein + RNA)
- Spectral Flow Cytometry (18+ colors)
- Microphysiological Systems (vessel-on-chip)
- Digital Histopathology / QuPath
- AI/ML Multi-Omic Integration

## Model Systems
- Rhesus Macaque (cross-gestational sampling)
- Human (clinical samples, biomarker validation)
- Mouse (genetic manipulation, fate mapping)
- MPS/Vessel-on-chip (therapeutic testing)

## Active NIH Funding
- R21 AI175753-01 (NIAID) — PI
- R01 HL163623-01A1 (NHLBI) — Site-PI
- R01 AI182082-01 (NIAID) — Co-I
- R01 HD103443-01 (NICHD) — Co-I

## Structured Data
JSON-LD (Schema.org) on every page. See [llms-full.txt](llms-full.txt) for complete documentation.

## Contact
Department of Obstetrics and Gynecology
University of Wisconsin-Madison School of Medicine and Public Health
1111 Highland Ave, Madison, WI 53705